The BRCA-P clinical trial is a breast cancer prevention trial which will enrol 2918 patients. It is open to women with a confirmed BRCA1 gene mutation who have not had a diagnosis of breast cancer. The aim of the trial is to study if using Denosumab is a safe and effective way of preventing breast cancer.
At least one in 400 women in the developed world carries the hereditary BRCA1 gene mutation. This mutation is associated with approximately 72% risk of developing breast cancer and 44% risk of developing ovarian cancer, over the course of a lifetime.
Denosumab is an antibody that switches off a molecule called RANK ligand. It is currently being used for strengthening the bones of people with osteoporosis and in people with breast and prostate cancer that has spread to the bones. Recent studies suggest switching off the RANK ligand can also inhibit the cells that cause breast cancer in women with a BRCA1 mutation.
If you are a woman between 25 and 55, with a known BRCA1 gene mutation, no current or previous breast cancer diagnosis, and not planning to have, or have not already completed surgery to remove both breasts, this trial might be suitable for you.
Participants of the trial will receive either Denosumab or a placebo drug every 6 months for 5 years.
In Queensland, you will be able to participate in the trial at the Royal Brisbane and Women's Hospital.
Read more on the Breast Cancer Trials page
Lipoedema vs Lymphoedema
Skin is soft and pliable vs Hard and thickened skin
Always bilateral vs Any part of your body
Symmetrical vs Asymmetrical
Feet and hands unaffected vs Can be affected
Tissue bruises easily vs Tissue does not bruise easily
Infection rare vs Infection common
Fat pads vs No fat pads
If you have lipoedema or lymphoedema, seek medical advice and the skills of a trained therapist. Those not trained in the treatment of these conditions may cause more harm than good. It is more than light touch and moving fluid!
Watch this short video by Jacqui on some of the treatment options for lymphoedema and lipoedema on the Gentle Hands Massage facebook page
I am a dual-trained Medical Oncologist and Palliative Care Physician who is passionate about empowering people living with cancer through education